I'm confident you could use them, probably without any concerns, but inside of a 300 wm, I'd personally personally test to search out some Federal GM215M primers, or large rifle magnum gold medal match primers, especially if you hunt in cold disorders. I have employed BR-2's in 7mm rem mags https://cruzetgqc.wssblogs.com/31579106/the-greatest-guide-to-cci-200